Internalization of the radioiodinated somatostatin analog [125I-Tyr3]octreotide by mouse and human pituitary tumor cells: increase by unlabeled octreotide.
نویسندگان
چکیده
منابع مشابه
Internalization of the Radioiodinated Somatostatin
Recently, we developed a technique that allows the in uiuo visualization in man of somatostatin receptor-positive neuroendocrine tumors after iv injection of [iZ31-Tyr3]octreotide or [“‘In-DTPA-nPhe’loctreotide. Radiotherapy of such tumors using somatostatin analogs coupled to OLor P-emitting radionuclides has been proposed as an application for radiolabeled somatostatin analogs. To develop thi...
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Somatostatin analogs currently used in the treatment of acromegaly and other neuroendocrine tumors inhibit hormone secretion and cell proliferation by binding to somatostatin receptor type (SST) 2 and 5. The antiproliferative pathways coupled to these receptors have been only partially characterized. The aim of this study was to evaluate the effect of octreotide and super selective SST2 (BIM231...
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ژورنال
عنوان ژورنال: Endocrinology
سال: 1995
ISSN: 0013-7227,1945-7170
DOI: 10.1210/endo.136.9.7649075